A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis

By J. Kendrew, G. Bodo, H. Dintzis, R. Parrish, H. Wyckoff, D. Phillips. 1958

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Citations in the corpus

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix (2019, background): “Since the first protein structures were determined in the 1950s (Kendrew et al., 1958; Perutz et al., 1960), the method has experienced many methodological and technological developments and is now considered to be quite mature (Wlodawer et al., 2013).”
The Poisson–Boltzmann equation for biomolecular electrostatics: a tool for structural biology (2002, methodology): “…protein and nucleic acid structures was hypothesized very early in structural biology (Watson and Crick, 1953; Pauling et al., 1951) and confirmed years later, after the first protein structure and DNA molecule had been solved by X-ray crystallography (Kendrew et al., 1958; Wing et al., 1980).”
Biological function derived from predicted structures in CASP11 (2016, background): “These complexes are: (1) T0787/T0788 (PDB: 4TVP69), a heterohexameric structure of a trimer of HIV gp120 each bound with gp41; (2) T0797/T0798 (PDB: 4OJK70), a heterotetramer of a coiled-coil homodimer from c-AMPdependent kinase 2 with one copy of human Ras11b bound to each helix; (3) T0840/T0841 (P”
Introduction to phasing (2010, methodology): “It was Max Perutz and John Kendrew who first applied the method to proteins (Perutz, 1956; Kendrew et al., 1958) by soaking protein crystals in heavy-atom solutions to create isomorphous heavy-atom derivatives (same unit cell, same orientation of the protein in cell), which gave rise to measurable…”
Protein Data Bank (PDB): The Single Global Macromolecular Structure Archive (2017, background): “Soon after X-ray structures of myoglobin [2, 3] and hemoglobin [4, 5] were published, the structural biology community began discussions as to how best to archive protein crystallographic findings and make them broadly available.”
Many ways to derivatize macromolecules and their crystals for phasing (2017, methodology): “The standard way of obtaining heavy-atom derivatives, introduced to protein crystallography as the first method of phasing macromolecular crystal structures by Perutz [3] and his followers [4, 5], is based on soaking native crystals in aqueous solutions containing salts of the appropriate metals.”
A glimpse of structural biology through X-ray crystallography. (2014, background): “Max Perutz and John Kendrew decided to pursue crystal structures of proteins—hemoglobin and myoglobin—beginning in the 1940s at the Cavendish Laboratory, University of Cambridge.”
Antarctic Marine Biodiversity: Adaptations, Environments and Responses to Change (2018, background): “Myoglobin has been recognised as important in oxygen relations in vertebrate muscles for over 50 years and was one of the first molecules to have its 3-dimensional structure elucidated using X-ray diffraction techniques (Kendrew et al. 1958).”
Intrinsic disorder and functional proteomics. (2007, background): “Some representative supportive examples include theoretical models postulated by Pauling (1), Fischer’s lock-and-key hypothesis (2), the first crystal structures of globular proteins (3,4) and of enzymes (5), and the studies that supported the refoldability proteins into their functional states (6,7”
Local Protein Structures (2007, background): “Before the first protein structure was solved [15], Pauling and Corey have proposed many stable local protein structures [1, 4, 5], including two”