Drugs from the deep: marine natural products as drug candidates.

By B. Haefner. Drug Discovery Today, 2003

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Medicinal and pharmaceutical uses of seaweed natural products: A review (2004, background): “The selection of samples for assays of biological activities useable in drug development is often based on ecological observations and includes specimens with unique (usually chemical) mechanisms for coping with environmental pressures (Haefner, 2003).”
Identification of the cellular site of polychlorinated peptide biosynthesis in the marine sponge Dysidea (Lamellodysidea) herbacea and symbiotic cyanobacterium Oscillatoria spongeliae by CARD-FISH analysis (2005, background): “Others on the growing list of marine-derived compounds under clinical investigation for use as anticancer agents include ecteinascidin, from the tunicate Ecteinascidia turbinate (phase III, Jimeno 2002); dolastatin 10, from the sea hare Dolabella auratium (phase II, Haefner 2003 ); and discodermoli”
A Historical Overview of Natural Products in Drug Discovery (2012, background): “Given that 70% of planet earth’s surface is covered by ocean, pharmaceutical companies began to realize that the ocean would possess unique biodiversity and may be a possible source for potential drug candidates [77].”