Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size.

By G. Kong, R. Braun, Mark W. Dewhirst. Cancer Research, 2000

633 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0f6835521770506cdfe2fd7501c8ec57c4f99bfe

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. (2004, background): “It has been demonstrated that macromolecules and small particles in the 60–400 nm size range will extravasate and accumulate in tumors [18–22] via a passive mechanism referred to as the ‘enhanced permeability and retention’ (EPR) effect [23,24].”
Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli (2010, background): “More applications are expected in new areas such as biosensing, cell labelling, drug targeting gene delivery, hyperthermia therapy, microelectronics, solar cells, electroluminescent devices, photocatalysis, detergent, cosmetics and antimicrobials (Ball 2001; Belloc et al. 2003; Kong et al. 2000; W”
Nanomedicine in cancer therapy (2023, background): “77,78 Consistent with these ﬁ ndings, Li et al. 79 reported that local hyperthermia (41 °C for 1 h) effectively increased tumor vasculature permeability and nanoparticle extravasation in all 4 tumor models tested, and showed that hyperthermia-enhanced nanoparticle extravasation lasted for…”
Improving Conventional Enhanced Permeability and Retention (EPR) Effects; What Is the Appropriate Target? (2013, background): “There are several other approaches to targeting the vasculature or stroma to promote vascular supply and vascular permeability in tumors, such as hyperthermia (65, 66), radiotherapy (67), high intensity focused ultrasound (68) and various mediators including bradykinin (52-55), nitric oxide-releasin”
Small particles, big impacts: A review of the diverse applications of nanofluids (2013, background): “hyperthermia treatments [82], [291], [293].”
Tumor Targeting via EPR: Strategies to Enhance Patient Responses (2018, background): “Hyperthermia can be used to increase the EPR effect especially in non-leaky tumors in which the baseline levels of nanomedicine accumulation are low [101,119,120].”
Overview of Therapeutic Ultrasound Applications and Safety Considerations (2012, background): “Research suggests that hyperthermia may be advantageous for drug delivery treatment using nanoparticles (Kong et al. 2000).”