Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles.

By D. O'Neal, L. Hirsch, Naomi J. Halas, J. Payne, Jennifer L. West. Cancer Letters, 2004

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Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study (2019, neutral): “GSNs (AuroShells) are composed of a silica core and a gold shell with a total diameter of ∼ 150 nanometers, and are designed to maximally absorb near-infrared light and convert it to heat (10 – 12).”
Applications of gold nanoparticles in cancer nanotechnology (2008, neutral): “PEG-coated nanoshells with peak absorption in the NIR region were intravenously injected into tumor-bearing nude mice (O’Neal et al 2004; Stern et al 2008).”
Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation (2010, background): “They also provide the ability to permit noninvasive photothermal ablation of tumors using ultrasound and microwaves in cases where surgery would be difficult.(67,74) However, care must be taken to minimize damage to surrounding normal tissue, and because of their unique geometry, penetration into sk”