Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

By S. Herzig, Etienne Raemy, S. Montessuit, J. Veuthey, Nicola Zamboni, B. Westermann, Edmund R. S. Kunji, J. Martinou. Science, 2012

719 citations recorded by the source corpus.

Subfields: Biochemistry, Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0f0f7a9feeeffdb110bfffe11e046807f0107825

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Gerald I. Shulman
2. V. Samuel
3. G. Brooks
4. Ralph J. Deberardinis
5. Navdeep S. Chandel
6. R. Medzhitov
7. M. Kotas
8. S. Weinberg

In Clinical Biochemistry

1. G. Brooks
2. Gerald I. Shulman

In Molecular Biology

1. Gerald I. Shulman
2. V. Samuel
3. Huafeng Zhang
4. Ping Gao
5. Linchong Sun
6. G. Brooks
7. Ajla T. Wasti
8. L. Gray

Citations in the corpus

• Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “The roles of compartmentalized acetyl-CoA metabolism in chromatin regulation and protein acetylation PDC Glucose-derived cytosolic pyruvate enters mitochondria by the mitochondrial pyruvate carrier (MPC), a heterodimer of MPC1 and MPC2 (Herzig et al., 2012).”
• Non-Alcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases (2017, positive): “Mitochondrial pyruvate transport is regulated by two key related proteins, mitochondrial pyruvate carrier 1 and 2, which form a transport complex on the inner mitochondrial membrane (Bricker et al., 2012; Herzig et al., 2012).”
• The Science and Translation of Lactate Shuttle Theory. (2018, methodology): “Following reports of discovery of themPC (Bricker et al., 2012; Herzig et al., 2012), and with access to our own custom antibodies to MCT1 as well as commercially available antibodies to the putative mPC, we obtained images assessing colocalization of MCT1 and mPC in L6 cells.”
• Regulation of pyruvate metabolism and human disease (2013, background): “In humans, the MPC is formed by two paralogous subunits, MPC1 and MPC2, in a currently unknown stoichiometry [1, 2].”
• Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport (2014, background): “MPC1 and MPC2 form a heterocomplex in the inner mitochondrial membrane, and loss of either component impairs pyruvate import, leading to citrate depletion (Bricker et al., 2012; Herzig et al., 2012).”