Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

Nature, 2015

677 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/0ef0a8164d9ba30bc2b1d7b977fdc3365d33dfe7

Citations in the corpus

• Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila (2017, positive): “Conversely, antidiabetic treatments, such as metformin administration and bariatric surgery were both found to be associated with a marked increase in the abundance of A. muciniphila (Figure 1) (Shin et al., 2014; Forslund et al., 2015; de la Cuesta-Zuluaga et al., 2017).”
• Machine Learning Meta-analysis of Large Metagenomic Datasets: Tools and Biological Insights (2016, positive): “course lead to overestimated prediction capabilities [44, 45], but we adopted here the same contrasting approach used in the original works.”
• Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer (2019, positive): “In all studies, however, 135 samples were collected prior to treatment, thus excluding cancer therapy as a potential confounding 136 effect [14, 21].”
• Parkinson’s Disease and PD Medications Have Distinct Signatures of the Gut Microbiome (2017, neutral): “The need to disentangle the gut microbiota signature of disease from that of medication and other confounders is becoming increasingly evident.(9) Studies linking the gut microbiome to PD include 1 conducted in mice that showed colonization with microbiota from PD patients enhanced neuroinflammation”
• Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid–Producing Microbiota in the Gut (2016, positive): “In contrast, four OTUs of Clostridiales including Clostridium celatum (Firmicutes| Clostridiaceae|OTU014), Clostridiaceae SMB53 (Firmicutes|Clostridiaceae| OTU026), Oscillospira (Firmicutes| Ruminococcaceae|OTU024), and Cellulosibacter alkalithermophilus (Firmicutes| Ruminococcaceae|OTU025) were mor”
• Akkermansia muciniphila is a promising probiotic (2019, positive): “This was confirmed by the correlation between an increased A. muciniphila level and the effectiveness of metformin in a recent study (Forslund et al., 2015).”
• Gut microbiota dysbiosis contributes to the development of hypertension (2017, positive): “P values were tested by Wilcoxon rank sum test and corrected for multiple testing with Benjamin & Hochberg method as others previously did [4, 25].”
• The mechanisms of action of metformin (2017, neutral): “were the most consistently observed effects on the microbiome across datasets from different countries [51].”