Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer
By J. Wirbel, Paul Theodor Pyl, E. Kartal, Konrad Zych, A. Kashani, A. Milanese, J. S. Fleck, A. Voigt, Albert Pallejà, R. Ponnudurai and 25 more. Nature Medicine, 2019
1,113 citations recorded by the source corpus.
Association studies have linked microbiome alterations with many human diseases. However, they have not always reported consistent results, thereby necessitating cross-study comparisons. Here, a meta-analysis of eight geographically and technically diverse fecal shotgun metagenomic studies of colorectal cancer (CRC, n = 768), which was controlled for several confounders, identified a core set of 29 species significantly enriched in CRC metagenomes (false discovery rate (FDR) < 1 × 10−5). CRC signatures derived from single studies maintained their accuracy in other studies. By training on multiple studies, we improved detection accuracy and disease specificity for CRC. Functional analysis of CRC metagenomes revealed enriched protein and mucin catabolism genes and depleted carbohydrate degradation genes. Moreover, we inferred elevated production of secondary bile acids from CRC metagenomes, suggesting a metabolic link between cancer-associated gut microbes and a fat- and meat-rich diet. Through extensive validations, this meta-analysis firmly establishes globally generalizable, predictive taxonomic and functional microbiome CRC signatures as a basis for future diagnostics. Cross-study analysis defines fecal microbial species associated with colorectal cancer.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/62b9cf8262232a54b36b08e6822fc0e815ce909a
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Citations in the corpus
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- Gut Microbiome: Profound Implications for Diet and Disease (2019, background): “Gut microbiota associated with colorectal cancer were recently shown to have an increase in genes associated with TMA lyase and protein catabolism, while microbe carbohydrate degradation pathways were depleted [156,157].”