Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases.

By V. Eremina, M. Sood, J. Haigh, A. Nagy, G. Lajoie, N. Ferrara, H. Gerber, Y. Kikkawa, J. Miner, S. Quaggin. Journal of Clinical Investigation, 2003

1,304 citations recorded by the source corpus.

Subfields: Nephrology, Oncology

View Paper: https://www.semanticscholar.org/paper/0ed311ee1cc400671f4eb6567e2c1689e7bccde8

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Citations in the corpus

Mechanisms of adverse effects of anti-VEGF therapy for cancer (2007, background): “…heterozygous deletion of VEGF in podocytes results in renal pathology manifested by loss of endothelial fenestrations in glomerular capillaries, proliferation of glomerular endothelial cells (endotheliosis), loss of podocytes, and proteinuria in mice (Eremina et al, 2003; Schrijvers et al, 2004).”
Vascular complications of diabetes: mechanisms of injury and protective factors (2013, background): “Conditional deletion of VEGF in podocytes resulted in a complete lack of endothelial and mesangial cells in mature glomeruli and death within the first day of life (Eremina et al., 2003).”
Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. (2014, background): “Notably, the glomerular podocytes in the graft tissue expressed vascular growth factors, including Vegfa and Ephrin B2, both of which are indispensable for endothelial capillary formation in the glomeruli (Figures 6X and 6Y) (Eremina et al., 2003; Takahashi et al., 2001).”
Autocrine VEGF signaling is required for vascular homeostasis. (2007, positive): “In particular, the presence of endothelial fenestrations in the pancreatic islands and glomeruli is dependent on constitutive signaling through VEGF (Eremina et al., 2003; Kamba et al., 2006).”
VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. (2006, background): “VEGF may also be important for the maintenance of the glomerular filtration barrier and may play a role in certain renal diseases (15).”
The spectrum of podocytopathies: a unifying view of glomerular diseases. (2007, background): “This point is emphasized by the critical requirement for vascular endothelial growth factor-A production by podocytes for normal endothelial and mesangial cell development and function.(3,4) However, the podocyte is the key organizer of glomerular development and maintenance.”
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer (2004, background): “VEGF inhibition during the early neonatal period results in growth arrest, endothelial-cell apoptosis and lethality, due primarily to kidney failur”