VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature.

By T. Kamba, Betty Y. Y. Tam, H. Hashizume, A. Haskell, B. Sennino, Michael R. Mancuso, Scott M. Norberg, S. O’Brien, Rachel B. Davis, L. Gowen and 6 more. American Journal of Physiology. Heart and Circulatory Physiology, 2006

786 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/376eb36b72bc51721cc21359a3350e55e451bc4b

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Citations in the corpus

Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. (2007, neutral): “study were significantly less than those previously reported to cause loss of capillaries and endothelial fenestrae in highly VEGF-dependent vascular beds.(29) Histological and ultrastructural examination of kidney, adrenal cortex, thyroid, and pancreas confirmed no deleterious action of the systemi”
Vascular endothelial growth factor (VEGF) signaling in tumor progression. (2007, background): “Kamba and co-workers used a variety of VEGF signal transduction inhibitors to determine which vascular beds in adult mice depend upon VEGF signaling for survival [281].”
Regulation of retinal blood flow in health and disease. (2008, background): “, 1998) and in vivo (Kamba et al., 2006) suggests that VEGF is capable of inducing fenestrations.”
VEGF receptor signalling ? in control of vascular function (2006, background): “Even a short-term, pharmacological block of the interaction between VEGFA and VEGFR2 in adult mice leads to vessel regressio”
Rapid vascular regrowth in tumors after reversal of VEGF inhibition. (2006, methodology): “To address these issues, we took advantage of approaches developed to study VEGF-dependent blood vessels in tumors and normal organs (6, 19, 20, 26).”
Mechanisms of adverse effects of anti-VEGF therapy for cancer (2007, background): “A survey of 18 organs of normal adult mice revealed significant regression of capillaries in some organs and not in others (Kamba et al, 2006; Baffert et al, 2006a).”
Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors (2008, background): “We have previously observed VEGF expression in virtually all vascularized adult tissues [50,65] and we and others have hypothesized that VEGF plays an important role in the maintenance of the adult vasculature [34,50].”
Autocrine VEGF signaling is required for vascular homeostasis. (2007, positive): “In particular, the presence of endothelial fenestrations in the pancreatic islands and glomeruli is dependent on constitutive signaling through VEGF (Kamba et al., 2006).”