Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
By D. Neill, S. Wong, A. Bellosi, R. Flynn, M. Daly, Theresa K.A. Langford, C. Bucks, C. Kane, P. Fallon, R. Pannell and 2 more. Nature, 2010
2,081 citations recorded by the source corpus.
Innate immunity provides the first line of defence against invading pathogens and provides important cues for the development of adaptive immunity. Type-2 immunity—responsible for protective immune responses to helminth parasites and the underlying cause of the pathogenesis of allergic asthma—consists of responses dominated by the cardinal type-2 cytokines interleukin (IL)4, IL5 and IL13 (ref. 5). T cells are an important source of these cytokines in adaptive immune responses, but the innate cell sources remain to be comprehensively determined. Here, through the use of novel Il13-eGFP reporter mice, we present the identification and functional characterization of a new innate type-2 immune effector leukocyte that we have named the nuocyte. Nuocytes expand in vivo in response to the type-2-inducing cytokines IL25 and IL33, and represent the predominant early source of IL13 during helminth infection with Nippostrongylus brasiliensis. In the combined absence of IL25 and IL33 signalling, nuocytes fail to expand, resulting in a severe defect in worm expulsion that is rescued by the adoptive transfer of in vitro cultured wild-type, but not IL13-deficient, nuocytes. Thus, nuocytes represent a critically important innate effector cell in type-2 immunity.
Subfields: Immunology, Physiology
View Paper: https://www.semanticscholar.org/paper/0ecd74dbc881492453d48d2a3cc24392d7866e14
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Citations in the corpus
- Systemically dispersed innate IL-13–expressing cells in type 2 immunity (2010, background): “The functional identification of Ih2 cells as a major IL-13–producing population is consistent with the original description of these cells (6) as well as more recent studies using IL-13 reporter mice (16).”
- Alternative activation of macrophages: mechanism and functions. (2010, background): “Cytokines in AAM Induction IL-4 and IL-13 are the prototypical direct inducers of AAMs, but other cytokines such as IL-33 and IL-25 amplify AAM induction indirectly, through Th2 cells (for review on CD4+ T cell heterogeneity, see O’Shea and Paul, 2010).”
- Plasmacytoid Dendritic Cells: Recent Progress and Open Questions (2011, background): “For instance, novel innate effector cell types have been described that appear similar to hematopoietic stem/progenitor cells, thus defying a conventional lineage assignment (63, 64).”
- Progressive loss of RORγt expression confers distinct functional fates to natural killer cell receptor-expressing RORγt+ innate lymphocytes (2010, positive): “IL-12 and IL-23 are related heterodimeric cytokines acting on NK- and LTi-derived cells that signal through related receptors (Oppmann et al., 2000).”
- Innate Lymphoid Cells: a new paradigm in immunology (2015, background): “Natural helper cells and nuocytes were described that expand in response to helminth infection and promote anti-worm and pro-allergic type 2 immune responses (8, 9).”