Innate immunity in Alzheimer's disease

By Michael T. Heneka, D. Golenbock, E. Latz. Nature Immunology, 2015

810 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/0ec1b5d80df543926d62a617c9a26d88575d5daa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. M. Colonna
2. Joachim L. Schultze
3. O. Butovsky
4. D. Holtzman
5. J. Long

In Physiology

1. M. Colonna

Citations in the corpus

• Microglia Function in the Central Nervous System During Health and Neurodegeneration (2017, background): “Microglia express multiple receptors that can bind Aβ and trigger inflammation, such as CD36 (105), TLR2, TLR4, TLR6 (17), and NLRP3 (106) (Figure 4).”
• Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases (2019, background): “The infiltration of monocytes in the brain through the blood-brain barrier was shown in murine models to be mediated via the CCL2-CCR2 axis with microglia and recruited monocytes located in the close proximity of deposited Aβ plaques (143), although some controversial studies based on irradiation ex”
• Microglia in Alzheimer’s disease (2018, background): “…gene expression signature overlaps significantly with changes in microglial mRNA profiles observed in other neurodegeneration-related models including PS19 tau transgenic, SOD1-G93A transgenic, and aged mice (Chiu et al., 2013; Holtman et al., 2015; Friedman et al., 2017; Keren-Shaul et al., 2017).”
• Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. (2017, background): “…mediated by activated microglia, reactive astrocytes and complement activation, that have been especially observed in the vicinity of amyloid plaques and even in the early stages of AD (Heppner et al., 2015; Clark et al., 2015; Heneka et al., 2015; Latta et al., 2015; Stoeck et al., 2014).”
• Low-grade inflammation, diet composition and health: current research evidence and its translation (2015, neutral): “…impact and mechanistic basis for the association between neuroinflammation and neuronal and overall CNS function, cognition and the risk of age-related cognitive decline and dementia is outside the scope of the present review, and has been the topic of many recent expert review articles (49–54) .”