Lipid rafts and signal transduction

By K. Simons, D. Toomre. Nature reviews. Molecular cell biology, 2000

6,420 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0eb567d9e642001fac69a4fe724d570b0ed43089

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. K. Simons
2. Yury A. Ermakov
3. Lei Liu
4. John Hancock
5. Ari Helenius
6. G. Nicolson
7. S. Mayor
8. David A. Drubin

In Molecular Biology

1. K. Simons
2. G. Nicolson
3. John Hancock
4. Yury A. Ermakov
5. Lei Liu
6. E. Taverna
7. I. Levitan
8. Raphael Zidovetzki

Citations in the corpus

• Genetic and cell biological analysis of integrin outside-in signaling. (2009, background): “Even a small increase in local concentration of signaling molecules as a result of partitioning into a lipid raft can, through amplification, initiate signaling cascades (Simons and Toomre 2000).”
• Studying protein dynamics in living cells (2001, background): “The lipid raft model suggests that cholesterol- and glycosphingolipid-enriched membrane microdomains organize certain proteins into functional domains during cell signalling and intracellular transpor”
• The complex of Arl2‐GTP and PDEδ: from structure to function (2002, background): “Furthermore, it has been shown that a variety of membrane-anchored proteins are not uniformly distributed within the plasma membrane but instead are enriched in discrete microdomains referred to as caveolae and rafts (Simons and Toomre, 2000), and that H-Ras moves into and out of these caveolae, whi”
• Actin assembly and endocytosis: from yeast to mammals. (2003, background): “Caveolae and lipid rafts are both enriched in cholesterol and sphingolipids and can be purified in a Triton-X insoluble fraction (Simons & Toomre 2000).”
• Lipid rafts: at a crossroad between cell biology and physics (2007, background): “Indeed, the field has been moving toward the concept that lipid-shelled proteins and protein nanoclusters can be triggered to aggregate by external influences, such as ligands, to produce larger functional domain”
• Lipid Rafts in the Maintenance of Synapses, Dendritic Spines, and Surface AMPA Receptor Stability (2003, background): “Several signal transduction pathways are organized in the context of lipid rafts (Simons and Toomre, 2000).”
• Cell-signalling dynamics in time and space (2006, background): “The localization of signalling proteins to distinct subcellular regions, such as internal membranes and membrane micro-environments (including lipid rafts) modulates signalling outputs 76,79 .”
• Human Immunodeficiency Virus Type 1 Assembly and Lipid Rafts: Pr55gag Associates with Membrane Domains That Are Largely Resistant to Brij98 but Sensitive to Triton X-100 (2003, background): “However, since cholesterol depletion affects many different cellular processes (28, 29, 44, 45), it could bring about reduction in HIV-1 particle production entirely through indirect effects as well.”
• Endocytosis Via Caveolae (2002, background): “Since these kinases are involved in signal transduction events, caveolae are thought to constitute especially active sites for signal transmission (9,54,55).”
• Dynamic Partitioning into Lipid Rafts Controls the Endo-Exocytic Cycle of the αL/β2 Integrin, LFA-1, during Leukocyte Chemotaxis (2005, background): “This is at variance with the requirement for ligand engagement observed for most receptors internalized via DRM (Simons and Toomre, 2000; Fullekrug and Simons, 2004) and suggests that, in the case of L/ 2, inducible connections with either DRM-resident proteins or with cytoskeletal proteins are invo”
• Direct visualization of Ras proteins in spatially distinct cell surface microdomains (2003, neutral): “The tools available to accurately assign proteins to specific domains in intact membranes are limited (Simons and Toomre, 2000).”