Bifidobacteria can protect from enteropathogenic infection through production of acetate

By S. Fukuda, Hidehiro Toh, K. Hase, K. Oshima, Yumiko Nakanishi, Kazutoshi Yoshimura, T. Tobe, J. Clarke, D. Topping, Tohru Suzuki and 6 more. Nature, 2011

2,237 citations recorded by the source corpus.

Subfields: Endocrinology, Food Science, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0eb47c53be71abfdc6c58606a6c4f7936b2cc6b3

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Citations in the corpus

Lactic Acid Bacteria Antimicrobial Compounds: Characteristics and Applications (2012, background): “[49] showed that the acetate produced by protective bacterial genus Bifidobacterium improves intestinal defense mediated by epithelial cells and thereby protects the host against infection of enterohemorrhagic Escherichia coli O157:H7.”
The microbial metabolites, short chain fatty acids, regulate colonic Treg cell homeostasis (2013, background): “These results may explain the benefits of dietary fibers and bacteria, such as clostridia and bifidobacteria (13) that can increase colonic luminal SCFA production and modulate inflammation in mice and humans.”
Bifidobacteria and Their Role as Members of the Human Gut Microbiota (2016, background): “Fifteen out of the 20 patients remained in remission throughout the trial, suggesting that administration of this bacterial cocktail is beneficial in maintaining remission from ulcerative colitis (Venturi et al., 1999; Gionchetti et al., 2000).”
Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “…levels of short-chain fatty acids (SCFAs, discussed in detail below), which have been shown in vitro and in vivo to support the integrity of the intestinal mucosa in a variety of ways (Fukuda et al., 2011; Gaudier et al., 2004; Macia et al., 2015; Willemsen et al., 2003; Wrzosek et al., 2013).”
Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health (2016, background): “Acetate has been found to be a key player in the ability of bifidobacteria to inhibit enteropathogens (Fukuda et al., 2011).”