Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain.
By D. Bharali, I. Klejbor, E. Stachowiak, Purnendu Dutta, Indrajit Roy, Navjot Kaur, E. Bergey, P. Prasad, M. Stachowiak. Proceedings of the National Academy of Sciences of the United States of America, 2005
607 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/0eadc3168de3316c8f1e91622aa4b3930b632f90
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In Molecular Biology
Citations in the corpus
- Sol-gel based materials for biomedical applications (2016, background): “With non-porous silica NPs, the surface modification showed also some effects on the DNA adsorption and the gene transfection, in which case however the DNA may not be fully protected against degradation by nucleases in the plasma [519,520].”
- Therapeutic Nanoparticles and Their Targeted Delivery Applications (2020, background): “In addition, silica-based nanoparticles have ability to interact with nucleic acids, which allows their use as targeted delivery vehicles [67].”
- In vitro toxicity of silica nanoparticles in human lung cancer cells. (2006, background): “…biomarkers for leukemia cell identification using optical microscopy imaging (Santra et al., 2001), cancer therapy (Hirsch et al., 2003), DNA delivery (Bharali et al., 2005; Gemeinhart et al., 2005), drug delivery (Venkatesan et al., 2005), and enzyme immobilization (Qhobosheane et al., 2001).”
- Mesoporous silica nanoparticles in medicine--recent advances. (2013, background): “Albeit efficient gene transfection was observed in vitro, the DNA may not be fully protected against degradation by nucleases in the plasma under these circumstances although transfection of genes has been demonstrated in vitro and in vivo using non-porous silica particles as carriers [65,66].”
- Mesoporous silica nanoparticles deliver DNA and chemicals into plants. (2007, background): “Each third of a segmented Petri dish contained a different media: (1) MS media, (2) MS þ 1 mM DTT and (3) MS þ 50 mM b-oestradiol.”
- Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. (2009, background): “, polyethyleneimine, polyamidoamine, and polylysine) through either covalent or electrostatic association.(12,14) 20 The gene delivery capabilities of these surface-modified materials have been demonstrated and may prove useful as alternatives to traditional viral vectors.”