Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains
By K. Imamura, N. Hishikawa, M. Sawada, T. Nagatsu, Mari Yoshida, Y. Hashizume. Acta Neuropathologica, 2003
743 citations recorded by the source corpus.
Subfields: Neurology, Physiology
View Paper: https://www.semanticscholar.org/paper/0e90df31b44ea05862ae37ad4fc858fe467fe191
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In Neurology
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In Physiology
Citations in the corpus
- Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. (2014, background): “The presence of activated microglial cells and elevated levels of several pro-inflammatory cytokines are evident in post-mortem examinations of the SN [256,257].”
- In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease. (2006, background): “More recently, microglial activation has also been described in the putamen, hippocampus, cingulate and temporal cortex of PD patients in post-mortem tissue (Imamura et al., 2003).”
- Microglia-mediated neurotoxicity: uncovering the molecular mechanisms (2007, background): “Numerous activated microglia are present in the vicinity of degenerating neurons in the substantia nigra of patients with Parkinson's disease and of those with other Parkinsonian syndrome”
- Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023, background): “The microglial activation and recruitment (microgliosis) process is accompanied by increased cytokine levels.(220) Elevated levels of cytokines (including IL1β, IL2, IL6, IFNγ, and TNFα) and CD4+ lymphocytes have been detected in both serum and CSF of PD patients.”
- Alternatively activated microglia and macrophages in the central nervous system. (2015, background): “In samples from Parkinson’s disease patients, MHC-II expresn is highly upregulated in substantia nigra, putamen and other ains areas (Imamura et al., 2003).”