WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement.

By Tadaomi Takenawa, H. Miki. Journal of Cell Science, 2001

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Cell migration: Rho GTPases lead the way. (2004, background): “Members of the WASp/SCAR/WAVE family of scaffold proteins are key regulators of actin polymerization (Takenawa and Miki, 2001).”
Dendritic mRNA: transport, translation and function (2007, background): “In non-neural cells, IRSp53 is activated by Rho, Rac1 and Cdc42 , and forms a complex with WAVE2 and Mena ) to nucleate actin filament assembl”
The WASP–WAVE protein network: connecting the membrane to the cytoskeleton (2007, background): “The VCA region binds to an actin monomer and to the ARP2/3 complex , leading to a burst of actin polymerization through the activation of the ARP2/3 complex, which mediates nucleation of actin polymerizatio”
SH3 domains: complexity in moderation. (2001, background): “WASP and its relatives play a pivotal role in organizing the actin cytoskeleton, a process that must be exquisitely controlled in time and space to allow directed movement (Higgs and Pollard, 1999; Mullins, 2000; Ramesh et al., 1999; Takenawa and Miki, 2001; Zigmond, 2000).”