Hot spots—A review of the protein–protein interface determinant amino‐acid residues

By Irina S. Moreira, Pedro Alexandrino Fernandes, Maria João Ramos. Proteins: Structure, Function, and Bioinformatics, 2007

733 citations recorded by the source corpus.

Subfields: Molecular Biology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/0e687d0fbd958871ffda552f4f3ec23d103d3524

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In Molecular Biology

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling (2011, background): “Curiously, the identified surface is composed largely of hydrophilic residues, which is unusual for protein–protein interfaces (41).”
Recent advances in the development of protein–protein interactions modulators: mechanisms and clinical trials (2020, background): “Tryptophan, arginine, and tyrosine are more likely to appear in hot-spots than other amino acids.(15,30) Because of the important role of these “hot-spots” amino acids, they are often used to design PPI drugs.”
BeAtMuSiC: prediction of changes in protein–protein binding affinity on mutations (2013, background): “Importantly, it has also been shown that a small fraction of the residues participating to the protein–protein interface are generally responsible for most of the binding afﬁnity (11–13).”
Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors (2010, methodology): “Using these criteria we placed the HIPP interactions into three broad categories: (1) receptors which contain a cleft for helix binding (Figure 3, panel a), as in the p53/HDM2 complex, where at least two nearby residues contribute strongly to binding; (2) extended interfaces that require multiple co”
Comprehensive Analysis of Loops at Protein-Protein Interfaces for Macrocycle Design (2014, unknown): “41 Using this approach, computational alanine scans of protein-protein complexes have yielded a wide range of information about the different roles specific residues play at PPI interfaces.”