Adipose tissue mass can be regulated through the vasculature

By M. Rupnick, D. Panigrahy, Chen-Yu Zhang, S. Dallabrida, Bradford B. Lowell, R. Langer, M. J. Folkman. Proceedings of the National Academy of Sciences of the United States of America, 2002

859 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/0e52be43e454738c0be23fcc2e7fbfb1e80ba3ea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. B. Spiegelman
2. E. Rosen
3. P. Trayhurn
4. M. Trujillo
5. P. Scherer
6. I. Wood
7. Haiming Cao
8. G. Hotamışlıgil

In Molecular Biology

1. B. Spiegelman
2. E. Rosen
3. M. Trujillo
4. P. Scherer
5. I. Wood
6. P. Trayhurn
7. G. Hotamışlıgil
8. Y. Sautin

In Physiology

1. B. Spiegelman
2. E. Rosen
3. P. Scherer
4. P. Trayhurn
5. M. Trujillo
6. I. Wood
7. Haiming Cao
8. G. Hotamışlıgil

Citations in the corpus

• Adipose tissue-derived factors: impact on health and disease. (2006, background): “In fact, blocking vascular endothelial growth factor or angiogenesis has a significant impact on adipose tissue homeostasis (3, 4), suggesting that this process is crucial to sustain normal adipose tissue function and for the support of its metabolic and endocrine functions.”
• 3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances (2018, background): “Future development of bioprinting can also potentially overcome vascularization challenge which is among the most important factors limiting bioprinting applications in tissue engineering [125].”
• The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017, neutral): “Chemical angiogenic inhibitors such as angiostatin, endostatin, and thalidomide as well as the VEGFR2-blocking antibody TNP470, have been tested in diet-induced obese mice or genetically obese ob/ob mice and shown to significantly reduce body weight and fat pad mass (88, 89).”
• Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. (2008, background): “Adipogenesis and angiogenesis are two closely related processes during adipose tissue enlargement, as shown in animal studies and in vitro models.(52,53) As adipocyte hypertrophy endures, local adipose tissue hypoxia may occur due to hypoperfusion since the diameter of fat cells overgrows the diffus”
• Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. (2005, neutral): “It is well established that tumor growth is angiogenesis dependent (43), and adipose tissue mass is also regulated by the vasculature (44).”
• Adipokines: inflammation and the pleiotropic role of white adipose tissue (2004, background): “That vascular development is an important issue in WAT function is indicated by the fact that adipose tissue mass is sensitive to angiogenesis inhibitors and can be regulated by its vasculature (Rupnick et al. 2002), and that several angiogenic factors are secreted by adipocytes (Claffey et al.”
• Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue (2009, background): “Destruction of local endothelial cells results in a reduction in fat mass during times of excess caloric intake independent of food intake (2, 30, 38).”