The initiation of liver development is dependent on Foxa transcription factors

By Catherine S. Lee, Joshua R. Friedman, J. Fulmer, Klaus H. Kaestner. Nature, 2005

612 citations recorded by the source corpus.

Subfields: Hepatology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/0ddfd9f09f8da810bd84046916882453c725023e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hepatology

1. G. Michalopoulos

In Molecular Biology

1. A. Soufi
2. K. Zaret
3. Manolis Kellis
4. J. Wysocka
5. Pouya Kheradpour
6. Jason S. Carroll
7. Olli-Pekka Kallioniemi
8. Matteo Pellegrini

In Surgery

1. G. Michalopoulos

Citations in the corpus

• Liver regeneration (2007, background): “There are several excellent studies in this subject, and they have implicated FGF growth factor family members and BMP family members, as inducing with hepatic anlagen commitment, specification, and differentiation (Lee et al., 2005; Battle et al., 2006; Zaret, 2006).”
• Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming (2015, positive): “Such activity is necessary for liver induction (Lee et al., 2005).”
• Modification of enhancer chromatin: what, how and why? (2013, background): “An archetypal pioneer factor is FOXA1, which is required for liver specification during development (Lee et al., 2005).”
• The evolution of Fox genes and their role in development and disease (2009, background): “However, overlapping and redundant functions can be maintained over long evolutionary periods; for example, FOXA1 and FOXA2 cooperate during liver and lung morphogenesi”
• Vertebrate Endoderm Development and Organ Formation (2009, background): “Consistent with this, the conditional deletion of both Foxa1 and Foxa2 from the mouse foregut prevents liver induction (Lee et al. 2005).”
• Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer (2011, background): “FoxA1/HNF-3a, a winged-helix transcription factor, is a member of the forkhead family, and it plays a critical role in the growth and differentiation of variety of organs, such as prostate, breast, lung and bladder (Lee et al, 2005; Friedman and Kaestner, 2006; Kaestner, 2010).”
• Systematic mapping of occluded genes by cell fusion reveals prevalence and stability of cis-mediated silencing in somatic cells (2014, background): “due to their ability to bind targets within closed chromatin (Cirillo et al. 2002; Lee et al. 2005; Friedman and Kaestner 2006).”
• Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments (2013, background): “The motifs we find specifically enriched in HepG2 (liver carcinoma) data sets match the known motifs for FOXA (EP300_disc3, HDAC2_disc2, and TCF12_disc2), HNF4 (FOXA_disc5 and HDAC2_disc5) and CEBP (EP300_disc2,6), three key liver regulators (70,81).”
• Pioneer transcription factors: establishing competence for gene expression. (2011, background): “While the two factors together are also not necessary for late fetal hepatocyte differentiation (Li et al. 2009), they are absolutely essential for the embryonic initiation of hepatic differentiation (Lee et al. 2005).”