Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin.

By A. Allen, G. Flemström. American Journal of Physiology - Cell Physiology, 2005

631 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Organic Chemistry, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/0dba112b1ec27f8024b9d867bca5efc8aee59dd4

How researchers see this paper

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In Nutrition and Dietetics

1. A. Cowieson
2. V. Ravindran
3. P. Selle
4. J. Wallace
5. R. Cone
6. M. Bedford

In Organic Chemistry

1. J. Wallace
2. R. Cone

In Pharmaceutical Science

1. J. Wallace
2. R. Cone
3. M. Esteban
4. J. Hanes

Citations in the corpus

• Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? (2008, background): “Mucus performs an important structural role in creating an unstirred layer on the mucosal surface which supports maintenance of a near-neutral pH at that surface as well as acting as a physical barrier against luminal pepsin (5).”
• Barrier properties of mucus. (2009, background): “In the stomach, mucus is secreted almost fast enough to prevent pepsin in the lumen from diffusing to the epithelial surface but not fast enough to prevent HCl, ethanol, and salts from reaching the epithelial surface [1].”
• Phytate and microbial phytase: implications for endogenous nitrogen losses and nutrient availability (2009, background): “Pepsin and HCl have been described as ‘endogenous aggressors’ and any hypersecretion would be met by additional outputs of mucus and NaHCO3 as a protective mechanism (Allen and Flemstrom, 2005).”