Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.
By J. Schauber, R. Dorschner, Alvin B. Coda, A. Büchau, Philip T Liu, David A. Kiken, Y. Helfrich, Sewon Kang, H. Elalieh, A. Steinmeyer and 4 more. Journal of Clinical Investigation, 2007
687 citations recorded by the source corpus.
Subfields: Immunology, Microbiology, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/0d9863522bc2dba9e500ce002648804f7138bfa5
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Citations in the corpus
- Vitamin D: The “sunshine” vitamin (2012, background): “[68] Another example of extrarenal regulation of 1α-hydroxylase is that the increased production of 1,25(OH)2D by keratinocytes in wounds[69] therefore provides a good estimate of vitamin D status, but regulation of 1α-hydroxylase activity should also be considered.”
- The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. (2012, neutral): “effects of 1,25-(OH)2D (66) (see Section VIII).”
- Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8 (2009, background): “Although the mechanisms controlling LL37 expression are still poorly understood, recent studies revealed the key involvement of the vitamin D3 and hypoxia response pathways, as well as the effect of various microorganisms on the production of LL37 (Liu et al., 2006; Schauber et al., 2007; Peyssonnau”
- Spinal Muscular Atrophy: Why do low levels of SMN make motor neurons sick? (2009, background): “Indeed, kidney cytochrome p450 (Cy27b1), a protein known to respond to stress stimuli, had the largest change in expression in the SMA sampl”
- From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. (2008, background): “Innate immune system Yes Skin injury enhances antimicrobial peptide synthesis through the VDR and the (62)”
- Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity (2008, background): “Studies using keratinocytes have also demonstrated induction of cathelicidin in response to autocrine synthesis of 1,25(OH) 2 D”
- Nonclassic actions of vitamin D. (2009, background): “Activation of TLRs leads to the induction of antimicrobial peptides and reactive oxygen species, which kill the organism.”
- Respiratory Epithelial Cells Convert Inactive Vitamin D to its Active Form (2008, background): “Prior studies have shown that histone acetylation is important for 1,25D3-driven expression of cathelicidin and CD14 in keratinocytes and in gastrointestinal cells (6, 51, 52).”
- Skin immune sentinels in health and disease (2009, background): “In addition, a link between AMP production, TLR expression and vitamin D has been described: keratinocytes surrounding a wound have increased expression of TLR2, LL37 and 25-hydroxyvitamin D 3 1α hydroxylase (also known as CYP27B1 ), which converts inactive 25-hydroxyvitamin D 3 (25(OH)VD 3 ) t”