Robustness and Evolvability in Living Systems

By Andreas Wagner. 2005

961 citations recorded by the source corpus.

Subfields: Management Science and Operations Research, Public Health, Environmental and Occupational Health

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Citations in the corpus

The globalization of socio-ecological systems: An agenda for scientific research (2006, background): “Robustness is the most recent of these terms (Wagner, 2005).”
A structural model of latent evolutionary potentials underlying neutral networks in proteins (2007, background): “The prevailing view on the emergence of new function at the molecular level stipulates that genes duplicate and the resulting redundancy facilitates adaptation since one of the gene copies becomes free to assume a new function (“neofunctionalization”), for example, via adaptive mutations (Ohno, 1970”
Evolution, the Extended Synthesis (2010, background): “Concepts such as evolvability (Wagner and Altenberg 1996; R. L. Carroll 2002; Love 2003b; Wagner 2005; Hansen 2006; Hendrikse et al. 2007; Colegrave and Collins 2008; Pigliucci 2008), for instance, did not exist in the literature before the early 1990s; phenotypic plasticity (West-Eberhard 1989;…”
Pervasive pairwise intragenic epistasis among sequential mutations in TEM-1 β-lactamase (2019, background): “Epistasis affects speciation [1, 2], the benefits of recombination and sex [3], genetic robustness [4, 5], and the predictability of evolution [6].”
On the application of statistical physics to evolutionary biology. (2009, background): “There has been considerable recent discussion of the evolution of redundancy (e.g. de Visser et al., 2003; Hansen, 2006; Wagner, 2005), stimulated by the surprising discovery that most genes in eukaryotes can be deleted without obvious ill-effects.”
The genetic code is nearly optimal for allowing additional information within protein-coding sequences. (2007, background): “This relative fitness advantage is much higher than minimal selectable fitness differences in microorganisms (Wagner 2005a), which is on the order of 10 ‫7מ‬ to 10”
Colloquium: Criticality and dynamical scaling in living systems (2017, background): “riticality might provide networks with an optimal balance between robustness and evolvability under changing conditions (Aldana et al., 2007; Gershenson, 2012; Kaneko, 2012; Torres-Sosa et al., 2012; Wagner, 2005). It remains to be claried how could adaptive (GellMann, 1994; Gros, 2008) and/or evolu”
Is evolvability evolvable? (2008, background): “Wagner's discussion of robustness and 'neutral spaces' in the G→P ma”
Stability effects of mutations and protein evolvability. (2009, background): “Redundancy, backup, and robustness, at different levels mask the effects of many mutations [5].”
The Evolution of Genetic Architecture (2006, background): “It has been argued that there is much less opportunity for direct selection for genetic canalization than there is for environmental canalization because there is much less mutational than environmental variation (e.g., Wagner 2005).”