Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.
By I. A. Roundtree, Chuan He. Trends in Genetics, 2016
1,910 citations recorded by the source corpus.
N(6)-Methyladenosine (m(6)A) is emerging as a chemical mark that broadly affects the flow of genetic information in various biological processes in eukaryotes. Recently, Xiao et al. reported that the nuclear m(6)A reader protein YTHDC1 impacts mRNA splicing, providing a transcriptome-wide glance of splicing changes affected by this mRNA methylation reader protein.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/0ccbdf76bac657e1e9dd24a39e211bcd0412c4f3
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In Molecular Biology
- Chuan He
- Samie R. Jaffrey
- Kate D. Meyer
- Hailing Shi
- Jiangbo W
- Syuzo Kaneko
- Masaaki Komatsu
- Ken Asada
Citations in the corpus
- YTH Domain: A Family of N6-methyladenosine (m6A) Readers (2018, background): “m(6)A has been attracting considerable attention because of its important roles in gene regulation [16], genome stability maintenance [17], as well as cell renewal and differentiation [18].”
- N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein (2017, neutral): “The low-complexity regions of the YTH proteins function in their recruitment to various cellular bodies (12,13,15).”
- Zc3h13 regulates nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal (2018, background): “At the molecular level, m6A has been demonstrated to regulate RNA stability, translation, splicing and export (Meyer et al., 2015; Sommer et al., 1978; Wang et al., 2014a; Wang et al., 2015; Xiao et al., 2016).”
- Rethinking m6A Readers, Writers, and Erasers (2017, background): “…as the epigenetic effects of certain noncoding RNAs (Dominissini et al. 2012; Meyer et al. 2012, 2015; Patil et al. 2016; X. Wang et al. 2014, 2015; Xiao et al. 2016). m6A was first detected in poly(A) RNA fractions in 1974 (Desrosiers et al. 1974, Perry & Kelley 1974), but the interest in m6A as…”
- YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs (2017, positive): “We confirmed the interactions between flag-tagged YTHDC1 and several members of the SR family which have been previously reported (Xiao et al., 2016) (Figure 5—figure supplement 1A).”
- Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism (2018, neutral): “YTHDC1 promotes exon inclusion by selectively recruiting or inhibiting different splicing factors such as Serine-arginine repeat (SR) proteins.(7) YTHDC1 also recognizes m(6)A on XIST and promotes XIST-mediated X chromosome silencing.”