At the acidic edge: emerging functions for lysosomal membrane proteins.

By E. Eskelinen, Yoshitaka Tanaka, P. Saftig. Trends in Cell Biology, 2003

674 citations recorded by the source corpus.

Subfields: Pathology and Forensic Medicine, Pediatrics, Perinatology and Child Health, Physiology

View Paper: https://www.semanticscholar.org/paper/0c740a527e6102f93c0f6f2d3e8893753aea322a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pathology and Forensic Medicine

1. E. Eskelinen
2. P. Saftig

In Physiology

1. P. Saftig
2. Judith Klumperman
3. E. Eskelinen
4. E. Kominami
5. T. Ueno
6. I. Tanida
7. M. Jäättelä
8. I. Slaninová

Citations in the corpus

• LAMP proteins are required for fusion of lysosomes with phagosomes (2007, background): “Two of the most abundant lysosomal components are the lysosome-associated membrane proteins 1 and 2 (LAMP-1 and LAMP-2, respectively) (Eskelinen et al, 2003).”
• Role for Rab7 in maturation of late autophagic vacuoles (2004, background): “Recent results have shown that autophagy also contributes to cell homeostasis in muscle, liver and pancreas (Eskelinen et al., 2003; Tanaka et al., 2000), as well as to development, growth regulation, cancer and longevity (Liang et al., 1999; Melendez et al., 2003).”
• Lysosomal cell death at a glance (2013, background): “The LMPpromoting effect of cysteine cathepsins might be due to the intralysosomal degradation of highly glycosylated lysosome-associated membrane proteins, which form a protective glycocalyx shield on the inner lysosomal membrane (Eskelinen et al., 2003; Fehrenbacher et al., 2008).”
• The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction. (2012, neutral): “Mutations in LAMP-2A cause Danon disease, and specifically affect CMA (Eskelinen et al., 2003; Fidziańska et al., 2007).”
• The lysosome: from waste bag to potential therapeutic target. (2013, background): “, 2009), where the most abundant are lysosome-associated membrane protein (LAMP)-1 and -2, lysosomal integral membrane protein (LIMP)-2, and CD63 (Eskelinen et al., 2003).”
• LC3 conjugation system in mammalian autophagy (2004, neutral): “In addition, autophagy has been shown to have significant associations with neurodegenerative diseases, cardiomyopathies, cancer, programmed cell death, and bacterial and viral infections (for reviews (Baehrecke, 2003; Bursch, 2001; Cuervo, 2003; Dorn, Dunn, & Progulske-Fox, 2002; Edinger & Thompson”
• Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function (2009, background): “LMPs reside mainly in the lysosomal limiting membrane and have diverse functions, including acidification of the lysosomal lumen, protein import from the cytosol, membrane fusion and transport of degradation products to the cytoplas”
• The cell biology of lysosomal storage disorders (2004, neutral): “implicated in LSDs so far,that is,sialin and cystinosin 4,5 .”