Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate

By L. Delamarre, Margit Pack, Henry C. Chang, I. Mellman, E. Trombetta. Science, 2005

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Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo (2007, background): “; however, some antigens can be remarkably long-live”
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. (2006, background): “Recent results show that DCs bear low levels of lysosomal proteases (Delamarre et al., 2005; Lennon-Dumenil et al., 2002) and that lysosome acidification in immature DCs is inefficient due to limited recruitment of the cytosolic subunits of the V-ATPase to endosomes and lysosomes, as compared to…”
Dendritic cells: translating innate to adaptive immunity. (2006, background): “This reflects two features: a relatively high intravacuolar pH [101] and a relative lack of proteases (rather than other lysosomal acid hydrolases) [102].”
Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting (2007, result): “Protease activity in phagosomes and lysosomes in DCs seems relatively modest when compared with macrophage”
The who, how and where of antigen presentation to B cells (2009, background): “DCs are widely considered to be the most efficient professional antigen-presenting cells and therefore are particularly important for the presentation of peptides in a complex with MHC molecules to naive T cell”