Identification of Human microRNA Targets From Isolated Argonaute Protein Complexes

By M. Beitzinger, Lasse Peters, Jia Yun Zhu, E. Kremmer, Gunter Meister. RNA Biology, 2007

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A human snoRNA with microRNA-like functions. (2008, methodology): “Cloned PCR products containing 5 0 adaptors, poly(A) tails, and 3 0 adaptor sequences were loaded onto an agarose gel ) (Beitzinger et al., 2007) and Ago2 (Ago2 [11A9]) (Rudel et al., 2008) ), some miRNAs are more highly represented in one or the other library, suggesting a preferential Ago binding.”
Origin, biogenesis, and activity of plant microRNAs. (2009, unknown): “, unpublished) prevalently contain factors that are homologous to hsAGO2-interacting proteins required for miRNAmediated translational repression in HeLa cells (Beitzinger et al., 2007).”
Hypoxia inducible mir-210 regulates normoxic gene expression involved in tumor initiation (2009, unknown): “In an effort to experimentally identify mir-210 target genes, we used a miRNP-IP approach that has been successfully used to identify miRNA targets (Beitzinger et al., 2007; Easow et al., 2007; Karginov et al., 2007).”
Getting to the root of miRNA-mediated gene silencing. (2008, background): “Indeed, biochemical purification of Argonautecontaining mRNA-protein complexes reveals partially nonoverlapping sets of mRNAs in association with individual Argonaute proteins, suggesting some degree of specificity in target selection (Beitzinger et al., 2007).”