Cellular stress response and apoptosis in cancer therapy.

By I. Herr, K. Debatin. Blood, 2001

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Apoptosis A Link between Cancer Genetics and Chemotherapy (2002, background): “Consistent with the latter possibility, cell death can sometimes proceed in the presence of caspasemetastatic melanoma, and overexpression of IAPs and heat shock proteins (Hsp), which can inhibit caspase-9 inhibitors (Herr and Debatin, 2001).”
Death and anti-death: tumour resistance to apoptosis (2002, unknown): “Treatment with these agents or with γ-irradiation causes cellular stress and finally cell deat”
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet (2002, background): “The exact mechanism of apoptosis induction is still unknown but would be predicted to involve activation of the mitochondrial pathway and subsequent activation of downstream caspases.(23) Several chemotherapeutic agents and anticancer drugs also act on mitochondria, although their exact mechanism of”