Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

By J. Wechsler, M. Greene, M. McDevitt, J. Anastasi, J. Karp, M. L. Beau, J. Crispino. Nature Genetics, 2002

787 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0b1148383fb81bbd078dfdf5845ccfc159a0a707

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. Daniel G. Tenen
2. Leonard I. Zon

In Molecular Biology

1. Leonard I. Zon
2. Stuart H. Orkin
3. Stephan W. Morris
4. Daniel G. Tenen
5. Bradley Efron

Citations in the corpus

• Hematopoiesis: an evolving paradigm for stem cell biology. (2008, background): “This observation is best exemplified by somatic mutations in GATA-1 in Down Syndrome-associated megakaryocytic leukemia (Wechsler et al., 2002), PU.1 and C/EBPa in myeloid leukemias (Mueller et al., 2002; Pabst et al., 2001), and Pax5 and other B cell factors (for example, E2A and EBF) in…”
• Rbm15 Modulates Notch-Induced Transcriptional Activation and Affects Myeloid Differentiation (2007, background): “In patients with Down syndrome who develop AML-M7 with trisomy 21, the 1;22 translocation is very rarely found; however, mutations in GATA1 that generate a truncated GATA1 protein are typically present (50).”
• Disruption of differentiation in human cancer: AML shows the way (2003, result): “A recent study reported that every paediatric patient that was analysed — with acute megakaryoblastic leukaemia associated with Down's syndrome — harboured mutations in GATA1 , whereas other M7 AML samples did no”