Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis

By Phillip J Hsu, Yunfei Zhu, Honghui Ma, Yueshuai Guo, Xiaodan Shi, Yuanyuan Liu, Meijie Qi, Zhike Lu, Hailing Shi, Jianying Wang and 8 more. Cell Research, 2017

916 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0afd66b4775f2cd841a2e3731d724a8851f74554

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. P. He
2. Hailing Shi
3. Chuan He

In Molecular Biology

1. Chuan He
2. P. He
3. Syuzo Kaneko
4. Masaaki Komatsu
5. Ken Asada
6. Ken Takasawa
7. Hailing Shi
8. Jiangbo W

Citations in the corpus

• Functions of N6-methyladenosine and its role in cancer (2019, background): “YTHDC2 enhances the translation of target RNA and reduces the abundance of target RNA [29]”
• Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia (2019, background): “The m6A reader proteins, YTHDF1/2/3, YTHDC1/2, and IGF2BP1/2/3, preferentially recognize m6A in mRNA (Dominissini et al., 2012; Hsu et al., 2017; Huang et al., 2018; Li et al., 2017a; Roundtree et al., 2017b; Shi et al., 2017; Wang et al., 2014a; Xiao et al., 2016).”
• Critical Roles of N6-Methyladenosine (m6A) in Cancer and Virus Infection (2020, background): “Furthermore, YTHDC2 is strongly expressed in testis and is essential for regulating m6A transcripts to ensure meiotic gene expression required for male and female fertility, and spermatogenesis [41,42].”
• RNA N6-methyladenosine modification in cancers: current status and perspectives (2018, background): “Of them, YTHDF2, YTHDF3, and YTHDC2 promote decay of m(6)A-modified mRNAs.(18,20,23) Interestingly, in”
• Methylation multiplicity and its clinical values in cancer (2021, neutral): “33).”
• YTH Domain: A Family of N6-methyladenosine (m6A) Readers (2018, background): “YTHDC2 is a putative RNA helicase [41,42] that forms a complex with the meiosis-specific coiled-coil domaincontaining protein (MEIOC) to regulate RNA levels during meiosis through recognizing m(6)A by its YTH domain (Figure 1) [42].”
• The potential role of RNA N6-methyladenosine in Cancer progression (2020, background): “with meiosis-specific coiled-coil domain (MEIOC) and 5′-3′ exoribonuclease 1 (XRN1) after identifying m6A, thus improving the translation efficiency of the target mRNA while reducing its abundance [35, 36].”
• Where, when and how: context-dependent functions of RNA methylation writers, readers, and erasers (2019, background): “Building on the understanding of its widespread prevalence on mRNA, recent work has uncovered that m6A plays an important role in gene expression regulation (Roundtree et al., 2017a), animal development (Frye et al., 2018), and human diseases (Hsu et al., 2017a).”
• Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism (2018, background): “They do not bind to m6A directly, but instead, m6A serves as a structural switch to alter the RNA structure, which renders transcripts more accessible for binding by HNRNPC and HNRNPG. Cytoplasmic m6A readers After being processed from precursor transcripts, mature mRNAs containing m6A are further r”
• m6A RNA methylation: from mechanisms to therapeutic potential (2021, positive): “…can selectively recognize m 6 A and exert a regulatory function on the m 6 A-marked mRNA. m 6 A readers include members of the YTH family, which bind m 6 A with their eponymous YTH domains (Wang et al , 2014a, 2015; Xiao et al , 2016; Hsu et al , 2017; Roundtree et al , 2017; Shi et al , 2017).”