The potential role of RNA N6-methyladenosine in Cancer progression

By Tianyi Wang, S. Kong, Mei Tao, S. Ju. Molecular Cancer, 2020

896 citations recorded by the source corpus.

N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA). m6A is installed by m6A methyltransferases (METTL3/14, WTAP, RBM15/15B, VIRMA and ZC3H13, termed “writers”), removed by demethylases (FTO, ALKBH5, and ALKBH3, termed “erasers”), and recognized by m6A-binding proteins (YTHDC1/2, YTHDF1/2/3, IGF2BP1/2/3, HNRNP, and eIF3, termed “readers”). Accumulating evidence suggests that m6A RNA methylation greatly impacts RNA metabolism and is involved in the pathogenesis of many kinds of diseases, including cancers. In this review, we focus on the physiological functions of m6A modification and its related regulators, as well as on the potential biological roles of these elements in human tumors.

View Paper: https://www.semanticscholar.org/paper/8e439b9a373b9dc08854fc2bedf4a5de5f7d5e03

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Citations in the corpus

• The role of m6A RNA methylation in cancer metabolism (2022, background): “reported that the complex role of m6A methylation in tumor progression in detail, which focused on the potential role of m6A methylation in distinct tumors [30].”