The role of oxidative damage and stress in aging.

By Alex F. Bokov, A. Chaudhuri, Arlan Richardson. Mechanisms of Ageing and Development, 2004

639 citations recorded by the source corpus.

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An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “Over the past two decades, many reviews have been published that contain extensive information regarding the oxidative stress theory of aging (7, 12, 21, 33, 57, 96, 142).”
Trends in oxidative aging theories. (2007, background): “The majority of studies verified the first aspect of Harman's hypothesis: that oxidative damage increases during aging (e.g., [17] [18] [19], reviewed in [19] [20] [21]).”
Is the Oxidative Stress Theory of Aging Dead? (2009, background): “For example, early studies on caloric restriction, which is the first andmost studied experimental manipulation shown to increase lifespan and retard aging, showed that oxidative damage to lipid, DNA, and protein was reduced in caloric restricted rodents compared to rodents fed ad libitum (for revie”
Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants (2013, background): “[19] proposed that general signalling failure with aging could be due to insufficient reactive species or wrong reactive species production although it is known that oxidative damage increases with age in a variety of tissues and animal models [19].”