Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells.
By K. Stenderup, J. Justesen, C. Clausen, M. Kassem. Bone, 2003
1,202 citations recorded by the source corpus.
Subfields: Genetics, Hematology, Physiology
View Paper: https://www.semanticscholar.org/paper/0aa0b02d67d2a06e6d7d40456f442cf45c8952ef
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In Physiology
Citations in the corpus
- Age‐related intrinsic changes in human bone‐marrow‐derived mesenchymal stem cells and their differentiation to osteoblasts (2008, background): “Another study with marrow aspirates showed that MSCs from young subjects had more population doublings in long-term culture than did the MSCs from older subjects (Stenderup et al., 2003; Kassem, 2006).”
- Replicative Senescence of Mesenchymal Stem Cells: A Continuous and Organized Process (2008, result): “Our results are in line with similar studies from other groups that demonstrate functional implications on differentiation potential [10,11,34,37].”
- Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, background): “found that MSCs derived from aging individuals exhibit a decreased maximal lifespan and an increased proportion number of SA beta-gal+ cells.(373) Bone marrow MSC senescence can be caused by telomere shortening, genotoxic stresses/DNA damage, strong mitogenic signals, oxidative stress, and distortio”
- Stem Cells Associated with Macroporous Bioceramics for Long Bone Repair: 6- to 7-Year Outcome of a Pilot Clinical Study (2007, neutral): “44,45 Hernigou et al . have reported the use of fresh bone marrow directly injected into a nonunion lesion to obtain bone healing, and they have evaluated the number and concentration of progenitor cells in the marrow sample.”
- Aging of mesenchymal stem cells. (2006, background): “Positive Simonsen et al. (2002) 22 + 46 (2) / 9.2 kb (15 PD) / Negative +TERT / 18.6 kb (75 PD) / (induced) Stenderup et al. (2003) 18–29 (6) Adherence, lymphoprep gradient Yes but not significant 10.4 kb 100 bp/PD Negative 66–81 (5) 9.1 kb ?”