IgH class switching and translocations use a robust non-classical end-joining pathway

By Catherine T. Yan, C. Boboila, Ellen Kris Souza, S. Franco, T. Hickernell, Michael M. Murphy, Sunil Gumaste, M. Geyer, Ali A. Zarrin, J. Manis and 2 more. Nature, 2007

633 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0a98badb3366dfe82c7e052ce6f949aa03d55ca6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. F. Batista
2. M. Lieber

In Molecular Biology

1. Wilhelm Palm
2. S. Boulton
3. T. de Lange
4. J. Reis-Filho
5. F. Batista
6. M. Lieber
7. de Lange
8. M. Blasco

Citations in the corpus

• RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection (2013, background): “The assembly of antibodies of different class requires that AID-induced DSBs are subject to deletional repair through classical and alternative NHEJ pathways (Stavnezer et al., 2008; Yan et al., 2007).”
• The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End Joining Pathway (2010, background): “NHEJ is largely responsible for joining these DSBs, but as mentioned above, elegant work has demonstrated the role of either ligase I or III, when ligase IV is missing (70).”
• Mechanism and regulation of class switch recombination. (2008, background): “XRCC4 or ligase IV deficiency is incompatible with life owing to problems during brain development, although human patients with hypomorphic mutations have been described, and mice with deficiencies have been created (120, 124, 125).”
• How shelterin protects mammalian telomeres. (2008, background): “For instance, in mouse cells with depleted telomere reserve due to telomerase deficiency, the formation of dicentric chromosomes does not require DNA ligase IV (131) and may therefore involve either the Alternative EndJoining pathway (39, 201) or HDR.”
• COMPLEX LANDSCAPES OF SOMATIC REARRANGEMENT IN HUMAN BREAST CANCER GENOMES (2009, positive): “It has previously been suggested that there exist multiple NHEJ repair processes which may be characterised by different lengths of overlapping microhomology at rearrangement junctions 21,22 .”