Mode of action of membrane active antimicrobial peptides.

By Y. Shai. Biopolymers, 2002

1,552 citations recorded by the source corpus.

Subfields: Ecology, Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/0a96b1f9876e7a1fa3d62f8d990cf14fdd2edc70

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Citations in the corpus

Analysis and prediction of antibacterial peptides (2007, neutral): “both vertebrates and invertebrates [2-10].”
Functional Composition, Nutritional Properties, and Biological Activities of MoroccanSpirulinaMicroalga (2019, background): “In fact, lipids kill microorganisms (bacteria, fungi, and yeasts) by reaching the bacterial membrane and causing their disintegration [78].”
Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent. (2009, background): “The antimicrobial activities of most peptides depend upon the formation of α-helica”
Mechanisms of Cellular Uptake of Cell-Penetrating Peptides (2011, background): “However, some AMPs are also toxic to the host cells [81].”
Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo (2018, background): “The outer surface of Gram-positive bacteria and Gram-negative bacteria contains teichoic and lipopolysaccharide, each conferring net negative charge on the surface allowing the initial electrostatic attraction with cationic AMPs [69,82].”
Studies on anticancer activities of antimicrobial peptides. (2008, methodology): “Some of the models used to identify the membranedisrupting process are carpet model [23], barrel-stave model [19], toroidal-pore wormhole model [24], and detergent-type membrane lytic mechanism [25,26].”
Antimicrobial Peptides (2013, background): “Antibacterial AMPs are the most studied AMPs to date and most of them are cationic AMPs, which target bacterial cell membranes and cause disintegration of the lipid bilayer structure [81,82].”
Melittin: a Membrane-active Peptide with Diverse Functions (2007, background): “Such a sequence of amino acids, coupled with its amphiphilic nature, is characteristic of many membrane-bound peptides and putative transmembrane helices of membrane proteins (Dempsey 1990; Shai 2002).”
Antimicrobial peptides: key components of the innate immune system (2012, background): “In one of these, higher peptide amounts on the membrane surface may eventually cause micellization in a detergent-like manner (Shai, 2002), although initial pore formation is not a prerequisite for this action.”