Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance

By I. Chopra, M. Roberts. Microbiology and Molecular Biology Reviews, 2001

4,190 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Microbiology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/0a7c0cbdeec3ef2157c5c4f606f079542b2c56fb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. T. Foster
2. T. Grossman
3. M. Roberts

In Microbiology

1. T. Foster
2. T. Grossman
3. M. Roberts

In Molecular Medicine

1. T. Grossman
2. Xinli An
3. Yong-guan Zhu
4. J. Munita
5. T. Foster
6. Jianqiang Su
7. H. Aarts
8. A. Roberts

Citations in the corpus

• Validating the AMRFinder Tool and Resistance Gene Database by Using Antimicrobial Resistance Genotype-Phenotype Correlations in a Collection of Isolates (2019, methodology): “We obtained compilations of resistance genes for several classes of ribosome-targeting antibiotics from Marilyn Roberts (personal communication) (43).”
• Acquired Antibiotic Resistance Genes: An Overview (2011, background): “…can be separated into two groups, typical, (e.g., chlortetracycline, doxycycline, minocycline, oxytetracycline, and tetracycline) and atypical tetracyclines (e.g., anhydrotetracycline and 6-thiatetracycline), see below (Rasmussen et al., 1991; Oliva and Chopra, 1992; Chopra and Roberts, 2001).”
• Bacterial resistance to oxytetracycline in Chilean salmon farming (2002, background): “…of this antibacterial has resulted in a growing selection of microbial resistance, involving either active efflux of the drug; ribosomal protection or enzymatic drug modification (Salyers et al., 1990; Speer et al., 1992; Levy, 1992a; Roberts, 1994; Taylor and Chau, 1996; Chopra and Roberts, 2001).”
• The prevalence of antibiotic resistance genes among Aeromonas species in aquatic environments (2014, background): “It should be emphasized that both genes code for an efflux pump that removes the drug from the cell (Chopra and Roberts 2001) and are located on plasmids (Szczepanowski et al. 2009).”
• Tetracycline antibiotics in the environment: a review (2013, background): “…by Smith and Rajan (2000) that tetracycline antibiotics could be benefit for the treatment of human infected with flarial nematodes, whereas Chopra and Roberts (2001) show that tetracycline antibiotics are effective to treat infections with Entamoeba histolytica, Giardia lamblia,…”
• A common mechanism of cellular death induced by bactericidal antibiotics. (2007, neutral): “…drugs predominantly inhibit ribosome function, targeting both the 30S (tetracycline family and aminocyclitol family) and 50S (macrolide family and chloramphenicol) ribosome subunits (Chopra and Roberts, 2001; Poehlsgaard and Douthwaite, 2005; Tenson et al., 2003; Weisblum and Davies, 1968).”
• Multidrug evolutionary strategies to reverse antibiotic resistance (2016, neutral): “Furthermore, the same mobility that allows resistance genes to spread rapidly would also accelerate their loss, relative to spontaneous mutations (73, 82, 83).”
• Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus (2014, background): “In GAS, tetracycline resistance is conferred by ribosome protection genes such as tet(M) or tet(O) (509).”
• Antibiotic resistance in food lactic acid bacteria--a review. (2005, background): “resistance to tetracycline by tet (M) includes also resistance to oxytetracycline, chlortetracycline, doxycycline and minocycline (Chopra and Roberts, 2001; Chopra, 1994).”