Nuclear receptors and the control of metabolism.

By G. Francis, Elisabeth Fayard, F. Picard, Johan Auwerx. Annual Review of Physiology, 2003

662 citations recorded by the source corpus.

How researchers see this paper

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Targeting bile-acid signalling for metabolic diseases (2008, background): “Several genes that have a role in HDL metabolism are FXR-α targets and have been reviewe”
Bile Acid Metabolism and Signaling (2013, positive): “The recent discovery that bile acids are endogenous ligands of a nuclear receptor farnesoid X receptor (FXR) has provided some mechanistic insight into the role of bile acids in the regulation of gene transcription (28, 31, 65), but the physiological relevance of the FXR-dependent pathways in regula”
Nuclear receptors — a perspective from Drosophila (2005, background): “Extensive studies over the past two decades have provided a detailed understanding of the molecular mechanisms by which nuclear receptors convert a hormonal signal into a transcriptional respons”
Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. (2004, positive): “Furthermore, the increased activity of these receptors regulates the transcription of a large number of genes involved in multiple aspects of lipid and lipoprotein metabolism (182).”