Lipid-protein interactions in biological membranes: a structural perspective.

By Anthony G. Lee. Biochimica et Biophysica Acta, 2003

843 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0a54942c628d05e11c7a87bc43d30bf42c43eb82

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In Atomic and Molecular Physics, and Optics

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Citations in the corpus

Protein-surfactant interactions: a tale of many states. (2011, background): “The tetrameric potassium channel KcsA binds anionic phospholipids at a “non-annular” site [249], originally identified through crystallography [250] and mass spectrometry [251].”
Membrane proteins, lipids and detergents: not just a soap opera. (2004, background): “Crystallography of membrane proteins has also provided an insight into the roles of specific membrane lipids in key biophysical functions within the protein–lipid environment [83,84].”
OPM: Orientations of Proteins in Membranes database (2006, background): “…X-ray scattering, neutron diffraction, electron cryo-microscopy, and NMR or infrared spectroscopy for several dozen cases, such as rhodopsin, lactose permease, mechanosensitive and potassium channels, or C2 domains (Frilingos et al., 1998, Lee 2003, Hubbell et al., 2003, Malmberg and Falke, 2005).”
TMDET: web server for detecting transmembrane regions of proteins by using their 3D coordinates (2005, background): “With the exception of a few tightly bound lipid molecules, the deposited experimental data have no direct indication that the protein is immersed into the membrane under native conditions, and do not contain information about the exact location of the lipid bilayer (Lee, 2003).”
Getting Across the Cell Membrane: An Overview for Small Molecules, Peptides, and Proteins (2015, background): “Membrane proteins can actively influence the organization of the membrane by forming specific and nonspecific interactions with lipids in the immediate boundary [7, 8].”
Bilayer thickness and membrane protein function: an energetic perspective. (2007, background): “In fact, when lipid molecules can be discerned and identified in membrane protein structures, they usually are resolved only in part (59, 60)—even at cryogenic temperatures— suggesting limited chemical specificity, significant disorder/mobility, or both.”
How lipids affect the activities of integral membrane proteins. (2004, background): “Most of the lipid molecules resolved in high-resolution crystal structures of membrane proteins are likely to be nonannular lipids, their strong binding to the protein leading to immobilization of at least part of the lipid molecule so that they appear in the high-resolution structure [7].”