A Self-Fulfilling Prophecy: C-Reactive Protein Attenuates Nitric Oxide Production and Inhibits Angiogenesis

By S. Verma, Chao-Hung Wang, Shu-hong Li, A. Dumont, P. Fedak, M. Badiwala, B. Dhillon, R. Weisel, Ren-Ke Li, D. Mickle and 1 more. Circulation, 2002

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The clinical implications of endothelial dysfunction. (2003, background): “synthase expression (91), suggesting that statins may spe-”
C-reactive protein (2012, neutral): “It has also been reported that CRP inhibits endothelial nitric oxide synthase (eNOS) activity [3,4].”
Guidelines for the Prevention of Stroke in Women: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2014, background): “In addition, higher levels of acute phase reactants such as C-reactive protein may decrease endothelial cell production of nitric oxide, which may in turn instigate a cascade of events leading to vasoconstriction, leukocyte adherence, platelet activation, oxidation, and thrombosis.(333,334) Attenuat”
Role of C-Reactive Protein at Sites of Inflammation and Infection (2018, background): “C-reactive protein has the ability to attenuate NO production with a marked reduction in in vitro angiogenesis, cell migration, and capillary-like tube formation by CRP at concentrations known to cause cardiovascular risk (91).”
Effects of exercise and diet on chronic disease. (2005, background): “Elevated CRP is associated with decreased nitric oxide (NO) bioavailability in human endothelial cells (395, 396), induces plasminogen activator inhibitor (82), and is independently Invited Review”