C-reactive protein

By Maitha Faraj, N. Salem. Radiopaedia.org, 2012

1,362 citations recorded by the source corpus.

CRP is phylogenetically a highly conserved plasma protein, with homolog in vertebrates and many invertebrates that participates in the systemic response to inflammation. Its plasma concentration increases during inflammatory states, a character that has long been employed for clinical purposes. CRP is a pattern recognition molecule, binding to specific molecular configurations that are typically exposed during cell death or found on the surfaces of pathogens. Its rapid increase in synthesis within hours after tissue injury or infection suggests that it contributes to host defense and that it is part of the innate immune response [8].

Subfields: Epidemiology, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/906e329fe2e6d143a210a6b032532833c19a61b4

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In Epidemiology

1. Nicola R. Sproston
2. J. Ashworth

Citations in the corpus

• Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. (2018, neutral): “Rising CRP concentrations furthermore activate neutrophils and monocytes, and promote the secretion of IL-6, IL-1β, and TNF-α (Black et al., 2004; Du Clos & Mold, 2004).”
• Role of C-Reactive Protein at Sites of Inflammation and Infection (2018, background): “Increased levels of CRP have been found in patients with appendicitis, cholecystitis, pancreatitis, and meningitis (44).”