The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins.

By Paul J. Harrison, P. Heath, S. Eastwood, P. Burnet, R. Pearson. 1995

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Human Hippocampal Neurogenesis Persists throughout Aging (2018, neutral): “A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript The volume of the DG and GCL-SGZ were determined in anterior, mid and posterior hippocampus separately, using the Cavalieri method (Harrison et al., 1995).”
The Human Brain Revisited: Opportunities and Challenges in Postmortem Studies of Psychiatric Disorders (2002, background): “However, tissue levels of many species of mRNAs are directly related to brain pH (Harrison et al. 1995; Kingsbury et al. 1995).”
Decreased glutamic acid decarboxylase67 messenger RNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia. (2000, background): “Postmortem brain pH was included as a covariate because it may reflect the integrity of some mRNA species.(25)”
Antidepressants increase neural progenitor cells in the human hippocampus (2009, background): “Brain pH determination (Harrison et al, 1995) and toxicological analyses were performed on cerebellar samples.”
Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia (2003, background): “Postmortem brain pH was included as a covariate because it may reflect the integrity of some mRNA species (Harrison et al., 1995).”