Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression

By S. Pelengaris, Michael Khan, Gerard I. Evan. 2002

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Reflecting on 25 years with MYC (2008, background): “Evan have shown that, in pancreatic islet cells, increased MYC expression and release of interleukin 1β (IL1β) is crucial for the initiation of angiogenesi”
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. (2004, background): “…and N-cadherin, as well as that of c-Myc and integrin signaling, raises the intriguing possibility of a complex network linking adhesion to specific signaling cascades in stem cells attached to their niche (Jamora and Fuchs 2002; Schwartz and Ginsberg 2002; Perez et al. 2003; Arai et al. 2004).”
MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. (2007, background): “The MYC protein contains a basic helix-loop-helix-leucine zipper domain (14, 15) that associates with the nuclear protein MAX to form a MYC-MAX heterodimeric transcription factor, which actively regulates the expression of various target genes involved in the control of cellular functions including ”
Oncomirs — microRNAs with a role in cancer (2006, background): “miRNAs associated with the MYC oncogene The MYC oncogene, which encodes a basic helix-loop-helix transcription factor, is often mutated or amplified in human cancers and has been shown to function as an important regulator of cell growth owing to its ability to induce both cell proliferatio”