Recycling Endosomes Supply AMPA Receptors for LTP

By Mikyoung Park, E. C. Penick, J. G. Edwards, J. Kauer, Michael D. Ehlers. Science, 2004

766 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/095224dea04cebd0ce55eb0dfb351b8e5786bae6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Richard L. Huganir
2. Kristen M. Harris
3. Jennifer N. Bourne
4. C. Yap
5. R. Malenka
6. B. Winckler
7. Z. Lasiecka
8. Max Vakulenko

In Cellular and Molecular Neuroscience

1. A. Citri
2. Richard L. Huganir
3. J. Shepherd
4. R. Malenka
5. E. Kandel
6. Kristen M. Harris
7. Jennifer N. Bourne
8. M. Mayford

In Molecular Biology

1. A. Citri
2. J. Shepherd
3. Richard L. Huganir
4. R. Malenka
5. Kristen M. Harris
6. Jennifer N. Bourne
7. M. Mayford
8. E. Kandel

Citations in the corpus

• Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. (2006, background): “AMPARs are highly dynamic and undergo rapid shuttling between the plasma membrane and internal recycling pools (Luscher et al., 1999; Park et al., 2004).”
• The cell biology of synaptic plasticity: AMPA receptor trafficking. (2007, background): “Activation of NMDA receptors can regulate the kinetics of recycling and significantly affect the relative amount of receptors that are maintained intracellularly versus on the surface (Park et al. 2004).”
• Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “LTP increases exocytosis of cargo from recycling endosomes, and this could be also the source of membrane for spine growth (Park et al., 2004).”
• Regulation of AMPA Receptor Trafficking and Synaptic Plasticity (2012, background): “Local endocytosis and recycling at EZ may provide a pool of mobile AMPARs to maintain synaptic strength during LTP [19 ,20].”
• Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. (2006, background): “1 maintains LTP remains to be determined.”
• Balancing structure and function at hippocampal dendritic spines. (2008, background): “LTP requires exocytosis-mediated insertion of AMPA receptors (Lu et al. 2001, Park et al. 2004, Kopec et al. 2006) and is accompanied by endocytosis of Kv4.”
• Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “An attractive model suggests that during LTP, recycling endosomes contribute AMPAR subunits to the synapse, as well as lipids and constituents which enlarge the synapse (Lisman and Zhabotinsky, 2001; Luscher et al, 2000; Park et al, 2004, 2006).”
• Synapses and memory storage. (2012, background): “Later it was found that the increase in response of the AMPA receptors to glutamate during LTP is attributable to the rapid insertion of new clusters of receptors in the postsynaptic membrane from a pool of intracellular receptors stored in recycling endosomes (Carroll et al. 1999; Shi et al. 1999; ”