Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

By Kenichiro Furuyama, Y. Kawaguchi, H. Akiyama, Masashi Horiguchi, S. Kodama, T. Kuhara, Shinichi Hosokawa, Ashraf Elbahrawy, T. Soeda, M. Koizumi and 10 more. Nature Genetics, 2011

829 citations recorded by the source corpus.

Subfields: Genetics, Hepatology, Surgery

View Paper: https://www.semanticscholar.org/paper/4f6e15836b39d675b49ca67270f9ca35c48b94de

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Hans Clevers
2. R. Weinberg
3. H. Begthel
4. Toshiro Sato
5. M. van de Wetering
6. Maaike van den Born
7. Alexander van Oudenaarden
8. Shalev Itzkovitz

In Hepatology

1. Hans Clevers
2. Charles M. Rice
3. R. Weinberg

In Surgery

1. Hans Clevers
2. R. Weinberg

Citations in the corpus

• Variation in cancer risk among tissues can be explained by the number of stem cell divisions (2015, background): “These stem cells are estimated to divide about once a year (131, 135).”
• Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver (2015, positive): “Proliferating bile-duct progenitor cells occur both during homeostasis (Furuyama et al., 2011) and after damage (Dorrell et al., 2011; Huch et al., 2013b; Shin et al., 2011).”
• Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids. (2018, positive): “Indeed, oval cells or atypical ductal cells expressing Epcam or Sox9 have long been regarded as bi-potential facultative stem/ progenitor cells (Dolle´ et al., 2015; Furuyama et al., 2011; Huch and Clevers, 2011; Huch et al., 2013).”
• Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis (2013, positive): “…as duct cells, to proliferate and differentiate towards acinar (Criscimanna et al , 2011; Furuyama et al , 2011), duct (Criscimanna et al , 2011; Furuyama et al , 2011; Kopp et al , 2011) and also endocrine lineages (including beta cells) (Xu et al , 2008; Criscimanna et al , 2011; Pan et al ,…”
• Sox2+ adult stem/progenitor cells are important for tissue regeneration and survival of mice (2011, positive): “Recent findings show that expression of the polycomb group protein Bmi-1 (Sangiorgi and Capecchi, 2008, 2009), the HMG box transcription factor Sox9 (Furuyama et al., 2011), the telomere subunit Tert (Breault et al., 2008; Montgomery et al., 2011), and the G-proteincoupled receptor Lgr5 (Barker et…”
• Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State (2012, background): “Supporting this notion, Sox9 has been shown by others to be expressed in SCs or progenitor cells in multiple epithelial tissues, including the skin, intestine, liver, and pancreas (Furuyama et al., 2011; Kopp et al., 2011; Nowak et al., 2008; van der Flier et al., 2009; Vidal et al., 2005).”