DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

By R. te Poele, A. L. Okorokov, L. Jardine, J. Cummings, S. Joel. Cancer Research, 2002

715 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/08c531d4cdfde767610201ce8ed9113f1c8a6672

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Citations in the corpus

• The essence of senescence. (2010, background): “Induction of p16INK4A is commonly seen in senescent mouse and human lesions in vivo also (te Poele et al. 2002; Collado et al. 2005; Michaloglou et al. 2005; Gray-Schopfer et al. 2006; Dhomen et al. 2009; Goel et al. 2009), while p53 and p21CIP1 induction can be evident, too; for example, in…”
• Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. (2011, background): “In addition, secreted factors from senescent cells may act in a paracrine manner to trigger senescence or, conversely, stimulate proliferation and/or transformation of adjacent immortalized cells (Krtolica et al. 2001; Wajapeyee et al. 2008).”
• Four faces of cellular senescence (2011, unknown): “…genes (Narita et al., 2003). p16INK4a, a tumor suppressor, is induced by culture stress and as a late response to telomeric or intrachromosomal DNA damage (Brenner et al., 1998; Robles and Adami, 1998; Ramirez et al., 2001; te Poele et al., 2002; Jacobs and de Lange, 2004; Le et al., 2010).”
• cGAS is essential for cellular senescence (2017, background): “The topoisomerase inhibitor etoposide is a cytotoxic anticancer agent that induces DNA damage and cellular senescence (35, 36).”
• Therapy-induced senescence in cancer. (2010, methodology): “Despite the relative inefficiency of these regimens for inducing senescence, these studies suggest that senescence may be a more prevalent tumor response to current anticancer therapy than previously realized (18,19).”
• Cellular senescence in cancer and aging. (2007, unknown): “Early studies using in vitro cultured cells showed that the infliction of various forms of DNA damage triggers senescence (Parrinello et al., 2003; te Poele et al., 2002).”
• Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “Analysis of senescence markers in human cancer biopsies from patients previously exposed to neoadjuvant chemotherapy confirmed the occurrence of TIS and its association to treatment outcome (12, 293, 316, 321).”