Mitochondrial form and function

By Jonathan R. Friedman, J. Nunnari. Nature, 2014

1,642 citations recorded by the source corpus.

Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells. Owing to their ability to produce ATP through respiration, they became a driving force in evolution. As an essential step in the process of eukaryotic evolution, the size of the mitochondrial chromosome was drastically reduced, and the behaviour of mitochondria within eukaryotic cells radically changed. Recent advances have revealed how the organelle's behaviour has evolved to allow the accurate transmission of its genome and to become responsive to the needs of the cell and its own dysfunction.

Subfields: Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/08bf5240b57d8e90a6e2aeb78a477d8c38c12501

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. H. McMahon

In Molecular Biology

1. Emmanuel Boucrot
2. Anthony A. Hyman
3. H. McMahon
4. T. Balla
5. Shovamayee Maharana

Citations in the corpus

• Membrane curvature at a glance (2015, background): “…they change according to the needs of the cell (e.g. mitochondrial fission or fusion) or the maturation of the Jo ur na l o f C el l S ci en ce organelle (e.g. formation or consumption of endocytic or synaptic vesicles) (Friedman and Nunnari, 2014; Haucke et al., 2011; Rafelski and Marshall, 2008).”
• Liquid-liquid phase separation in biology. (2014, background): “Many compartments are separated by membranes, such as mitochondria, which contain a chemical environment necessary to make ATP (Friedman & Nunnari 2014), or lysosomes (Luzio et al. 2007), which contain components necessary to destroy other proteins.”
• Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq (2021, neutral): “Discovery of stress-specific regulation of the mitochondrial genome Mitochondria arose from the engulfment and endosymbiotic evolution of an ancestral alphaproteobacterium (Friedman and Nunnari, 2014).”