TGFβ signalling in context
By J. Massagué. Nature reviews. Molecular cell biology, 2012
2,886 citations recorded by the source corpus.
The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more than a decade ago. Since then, the concept of how the TGFβ signal travels from the membrane to the nucleus has been enriched with additional findings, and its multifunctional nature and medical relevance have relentlessly come to light. However, an old mystery has endured: how does the context determine the cellular response to TGFβ? Solving this question is key to understanding TGFβ biology and its many malfunctions. Recent progress is pointing at answers.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/07f09f5f17eb777b03b4ba43b456d15b9084dfb8
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Citations in the corpus
- Oxidative Stress in Cancer (2020, background): “In this situation, binding of TGF-β to its cell-surface receptor, TGFβ receptor type 1 (TGFβR1), or TGFβR2, causes phosphorylation of SMAD2 and SMAD3 that, in turn, trimerize with SMAD4 and, following nuclear translocation, positively regulate SNAIL, SLUG, TWIST1, and ZEB1 (Massague, 2012).”
- Angiogenic signaling pathways and anti-angiogenic therapy for cancer (2023, background): “During the initial stage of tumorigenesis, TGF-β acts as a suppressor that induces apoptosis and confines pre-cancerous cells.(216,218) But in mature tumor tissue, the aggressiveness of the tumor is awakened by TGF-β, which encourages various procancer activities, including epithelial-mesenchymal tr”