Signal-processing machines at the postsynaptic density.

By Mary B. Kennedy. Science, 2000

792 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/0774c21159ed4527e2de67db831b1757e649d2bc

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Mechanism and role of PDZ domains in signaling complex assembly. (2001, background): “The PDZ-containing protein SHANK is also a component of the PSD, and this protein appears directly or indirectly to crosslink the scaffold proteins PSD-95 and GRIP, perhaps acting as a 'scaffold of scaffolds' (Sheng and Kim, 2000; Kennedy, 2000; Naisbitt et al., 1999; Tu et al., 1999).”
Concepts of neural nitric oxide-mediated transmission (2008, background): “CaMKII, a co-resident with NMDA receptors and nNOS at synapses (Kennedy, 2000), was found to phosphorylate the enzyme on serine-847 and inhibit NO formation by 50%, probably by affecting Ca2+ ⁄ calmodulin binding (Hayashi et al., 1999; Komeima et al., 2000).”
COORDINATION OF SIZE AND NUMBER OF EXCITATORY AND INHIBITORY SYNAPSES RESULTS IN A BALANCED STRUCTURAL PLASTICITY ALONG MATURE HIPPOCAMPAL CA1 DENDRITES DURING LTP (2011, background): “Free polyribosomes indicate synthesis of cytoplasmic proteins, hence candidate molecules might include PSD95 (Gray et al., 2006; Ehrlich et al., 2007), CAMKII (Otmakhov et al., 2004; Rose et al., 2009) or other PSD-associated molecules involved in stabilizing receptors (Kennedy, 2000).”
Could a Neuroscientist Understand a Microprocessor? (2016, background): “Obviously the brain is not a processor, and a tremendous amount of effort and time have been spent characterizing these differences over the past century [18, 45, 19].”
Regulation of NMDA Receptor Subunit Expression and Its Implications for LTD, LTP, and Metaplasticity (2008, background): “Through the PDZbinding motifs, they interact with membrane-associated guanylate kinase (MAGUK) family of synaptic scaffolding proteins that in turn associate with important synaptic signaling molecules and tether NMDARs to intracellular signaling pathways (Kennedy, 2000).”
Regional aerobic glycolysis in the human brain (2010, background): “A more extended view of the role of aerobic glycolysis in the generation of ATP has emerged from the observation that glycolytic enzymes are found in the postsynaptic density (PSD) (34), a very dynamic complex containing various ion channel proteins, synaptic receptors, and signal transduction pathw”
The hardware lottery (2020, neutral): “Humans have highly optimized and speciﬁc pathways developed in our biological hardware for diﬀerent tasks (Von Neumann et al., 2000; Marcus et al., 2014; Kennedy, 2000).”