A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans

By Scott Kennedy, Duo Wang, Gary Ruvkun. Nature, 2004

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Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. (2007, background): “NMTGS is the result of chromatin remodeling that appears to be induced by small interfering RNA (siRNA), since NMTGS is inhibited by overexpressing the exonuclease 3 hExo (Bühler et al. 2005) that degrades double-stranded siRNA (Kennedy et al. 2004).”
Small RNAs and Their Roles in Plant Development (2009, background): “Eri-1 from C. elegans acts on small RNA duplexes to remove the 2-nt 3′ overhangs in vitro and limits the efficiency of RNAi in vivo (Kennedy et al. 2004).”