Metabolite profiling for plant functional genomics

By Oliver Fiehn, Joachim Kopka, Peter Dörmann, Thomas Altmann, R. Trethewey, Lothar Willmitzer. Nature Biotechnology, 2000

2,074 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/06a6abcd632dba72d9fe95d558daea8a1e29e2ac

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Ecological metabolomics: overview of current developments and future challenges (2011, background): “Metabolomics coupled with other omics approaches Metabolomics allows the determination of the phenotype response directly (Fiehn et al. 2000), whereas transcriptomics and proteomics analyze the way genome expression translates to biological response, thus allowing us to detect the genes that are…”
Flux balance analysis in the era of metabolomics (2006, background): “microbial [5], plant [6, 7] and human [8] systems.”
Natural products and plant disease resistance (2001, background): “Recent improvements in high-throughput metabolite profiling, using gas chromatography or liquid chromatography linked to mass spectrometry, now make it possible to screen for changes in the levels of several hundred plant metabolites in a single sampl”
Exploring the Temperature-Stress Metabolome of Arabidopsis1[w] (2004, methodology): “Metabolite samples were derivatized as described by Fiehn et al. (2000) and Roessner et al. (2000), analyzed by an MD 800 GC-MS system 4166 Plant Physiol.”
Highly sensitive feature detection for high resolution LC/MS (2008, background): “Background Metabolomics aims at the unbiased and comprehensive quantification of metabolite concentrations in organisms, tissues, or cells [1,2].”
Responses of the pea (Pisumsativum L.) leaf metabolome to drought stress assessed by nuclear magnetic resonance spectroscopy (2008, methodology): “The use of NMR spectroscopy for studying plant metabolism in a holistic manner predates the term ‘‘metabolomics’’ ( Fiehn et al. 2000 ) by some years (Moore et al. 1983; Belton and Ratcliffe 1985; Ratcliffe 1987; Fan 1996).”
Secondary Metabolites as Plant Traits: Current Assessment and Future Perspectives (2002, background): “Today, EI mass spectral libraries, containing tens of thousands of spectra of identified compounds, turn GC–MS technology into one of the most powerful tools for obtaining metabolite profiles of particular plant tissues (Fiehn et al., 2000, 2001).”
Correlative GC-TOF-MS-based metabolite profiling and LC-MS-based protein profiling reveal time-related systemic regulation of metabolite–protein networks and improve pattern recognition for multiple biomarker selection (2005, methodology): “In the field of metabolomics, PCA has become a popular tool for visualizing datasets and for extracting relevant information (Fiehn et al., 2000; Viant, 2003; Goodacre et al., 2004).”
GMD@CSB.DB: the Golm Metabolome Database (2005, methodology): “…whole genomes of various organisms (Goffeau et al., 1996; Blattner et al., 1997; The Arabidopsis Genome Initiative, 2000; Lander et al., 2001) facilitate the development of technology platforms to monitor the cellular inventory (Fiehn et al., 2000; Lockhart and Winzeler, 2000; Corbin et al., 2003).”
Observing and Interpreting Correlations in Metabolic Networks (2003, methodology): “With these capabilities at hand, the use of metabolomic methods to significantly extend and enhance the power of existing functional genomics approaches has already been demonstrated (Fiehn et al., 2000).”