Role of integrins in regulating epidermal adhesion, growth and differentiation

By Fiona M. Watt. EMBO Journal, 2002

692 citations recorded by the source corpus.

Subfields: Cell Biology, Rehabilitation, Urology

View Paper: https://www.semanticscholar.org/paper/056fd919b54c205cbeae18e125c1ece13ca972f4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Elaine Fuchs
2. C. Blanpain
3. V. Horsley
4. A. Trumpp
5. Anne Wilson
6. G. Schultz
7. Lisa Polak
8. A. Geoghegan

In Rehabilitation

1. Elaine Fuchs
2. C. Blanpain
3. V. Horsley
4. G. Schultz
5. Lisa Polak
6. A. Geoghegan
7. A. Wysocki
8. W. Lowry

In Urology

1. Elaine Fuchs
2. C. Blanpain
3. V. Horsley
4. G. Schultz
5. Lisa Polak
6. A. Geoghegan
7. A. Wysocki
8. W. Lowry

Citations in the corpus

• Epithelial stem cells: turning over new leaves. (2007, positive): “In addition, focal adhesions and hemidesmosomes regulate the dynamics of adhesion and detachment of cells and their underlying ECM, thus mediating cell migration, stratification, and differentiation (Fuchs and Raghavan, 2002; Watt, 2002).”
• α4β1- and α6β1-integrins are functional receptors for midkine, a heparin-binding growth factor (2004, neutral): “They play key roles in morphogenesis, inflammation and tumor invasion (Hood and Cheresh, 2002; Watt, 2002; Bokel and Brown, 2002; Brakebusch et al., 2002).”
• Interactions between extracellular matrix and growth factors in wound healing (2009, positive): “For instance, integrin binding is necessary for keratinocyte motility, as was first demonstrated with adhesion blocking antibodies.(59) Angiogenesis is an example of a process that occurs during wound healing that requires adhesion of cells to the ECM in order for them to respond to growth factors.”
• c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. (2004, positive): “In addition to the more recent implication of cadherins in stem-cell niche interactions, there is ample evidence to support an important role for integrins in adult stem cell function (Jones and Watt 1993; Pruijt et al. 1998; Whetton and Graham 1999; Hynes 2002; Lapidot and Petit 2002; Velders et al”
• Anoikis: an emerging hallmark in health and diseases (2012, neutral): “Indeed, while normal epithelial cells express collagen receptor α2β1 and laminin receptors α3β1 and α6β1 [79,80], hyperproliferating epithelial cells over-express αvβ5 and αvβ6 integrins [81,82] and the anoikis-resistant squamous carcinoma cells over-express αvβ6 with respect to αvβ5 [83,84].”
• Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. (2004, positive): “FACS was used to isolate pure populasis in most epithelial cells are influenced heavily by associated basal lamina (Werb, 1997; Martin et al., 2002; tions of K14-GFP-actin expressing ␣6 low CD34 high , ␣6 high CD34 high , ␣6 low CD34 Ϫ , ␣6 high CD34 Ϫ , and GFP ϩ keratino- Watt, 2002).”